Is levofloxacin necessary to prevent postoperative infections of auricular second-intention wounds?

Dermatol Surg. 2008 Jan;34(1):26-30; discussion 30-1. doi: 10.1111/j.1524-4725.2007.34004.x. Epub 2007 Dec 5.


Background: Surgeons may prescribe oral quinolones after auricular procedures to prevent postoperative infections, especially those caused by Pseudomonas aeruginosa.

Objective: This study compares the efficacy of levofloxacin and local wound care to local wound care alone in preventing postoperative infection of auricular second-intention wounds.

Materials and methods: This study was a prospective, randomized trial of 84 consecutive patients (82 in the final analysis) who underwent Mohs micrographic surgery for an auricular neoplasm and had a wound left to heal by second intention. After surgery, patients were randomly assigned to receive either local wound care or local wound care with concurrent 500 mg of levofloxacin by mouth daily.

Results: Overall, 85.4% of patients had no complications. Complications included 12.2% of patients with inflammatory chondritis and 2.4% of patients with infection. No infections with P. aeruginosa were observed. No statistical significance was observed between the two treatment groups.

Conclusion: Levofloxacin is not necessary to prevent postoperative infections of auricular second-intention wounds after Mohs surgery.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / therapeutic use*
  • Ear Auricle / surgery*
  • Female
  • Humans
  • Levofloxacin*
  • Male
  • Middle Aged
  • Mohs Surgery / adverse effects*
  • Ofloxacin / therapeutic use*
  • Prospective Studies
  • Surgical Wound Infection / etiology
  • Surgical Wound Infection / prevention & control*
  • Wounds and Injuries / drug therapy
  • Wounds and Injuries / etiology


  • Anti-Bacterial Agents
  • Levofloxacin
  • Ofloxacin