Microarray-based expression profiling and informatics

Curr Opin Biotechnol. 2008 Feb;19(1):26-9. doi: 10.1016/j.copbio.2007.10.008. Epub 2007 Nov 28.

Abstract

Microarray-based expression profiling is a powerful technology for studying biological mechanisms and for developing clinically valuable predictive classifiers. The high-dimensional read-out for each sample assayed makes it possible to do new kinds of studies but also increases the risks of misleading conclusions. We review here the current state-of-the-art for design and analysis of microarray-based investigations.

Publication types

  • Review

MeSH terms

  • Algorithms
  • Biotechnology
  • Computational Biology
  • Gene Expression Profiling / classification
  • Gene Expression Profiling / statistics & numerical data*
  • Humans
  • Oligonucleotide Array Sequence Analysis / classification
  • Oligonucleotide Array Sequence Analysis / statistics & numerical data*
  • Phenotype