Variants in the FTO gene are associated with common obesity in the Belgian population

Mol Genet Metab. 2008 Apr;93(4):481-4. doi: 10.1016/j.ymgme.2007.10.011. Epub 2007 Dec 4.

Abstract

Three independent studies, of which two genome-wide scans, have reported an association between SNPs in the FTO (Fat mass and obesity associated) gene and obesity, in different European cohorts. We selected the SNPs with the strongest evidence for association from the first two studies and genotyped 1099 obese patients and 268 healthy control individuals. Both SNPs were significantly associated with obesity, enabling us to replicate earlier findings from Caucasian cohorts in a Belgian population sample.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alpha-Ketoglutarate-Dependent Dioxygenase FTO
  • Belgium / epidemiology
  • Body Mass Index
  • Cohort Studies
  • European Continental Ancestry Group / genetics
  • Genetic Variation
  • Humans
  • Obesity / genetics*
  • Polymorphism, Single Nucleotide
  • Proteins / genetics*

Substances

  • Proteins
  • Alpha-Ketoglutarate-Dependent Dioxygenase FTO
  • FTO protein, human