Splenic peliosis in a patient with aplastic anemia during danazol therapy

Int J Hematol. 2007 Nov;86(4):329-32. doi: 10.1532/IJH97.07078.


We experienced a case of danazol-induced splenic peliosis. A 42-year-old woman had taken danazol for refractory aplastic anemia for 2 years. Her anemia gradually became aggravated, and the patient complained of intermittent left upper-abdominal pain. Because computed tomography scanning showed multiple blood-filled cavities in the enlarged spleen without intraperitoneal hemorrhage, a splenectomy was emergently performed. This report is the first of a case of splenic peliosis developing during danazol therapy for aplastic anemia. The possible association between the administration of anabolic steroids or danazol and the development of peliosis is discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anemia, Aplastic / drug therapy*
  • Anemia, Aplastic / pathology
  • Danazol / adverse effects*
  • Danazol / therapeutic use*
  • Female
  • Humans
  • Splenic Diseases / chemically induced*
  • Splenic Diseases / pathology*
  • Splenic Diseases / surgery
  • Tomography, X-Ray Computed


  • Danazol