Holotranscobalamin remains unchanged during pregnancy. Longitudinal changes of cobalamins and their binding proteins during pregnancy and postpartum

Anne L Morkbak; Anne-Mette Hvas; Nils Milman; Ebba Nexo

doi:10.3324/haematol.11636

Holotranscobalamin remains unchanged during pregnancy. Longitudinal changes of cobalamins and their binding proteins during pregnancy and postpartum

Haematologica. 2007 Dec;92(12):1711-2. doi: 10.3324/haematol.11636.

Authors

Anne L Morkbak¹, Anne-Mette Hvas, Nils Milman, Ebba Nexo

Affiliation

¹ Dept. of Clinical Biochemistry, Aarhus University Hospital, Aarhus Sygehus, Denmark. almor@as.aaa.dk

PMID: 18056000
DOI: 10.3324/haematol.11636

Abstract

We confirm a decrease in cobalamins during pregnancy, and report that the active part of cobalamins (holotranscobalamin, holoTC) remains unchanged. The decrease in cobalamins is explained by a decreased holohaptocorrin (holoHC), suggesting that holoTC rather than cobalamins should be used as a marker of vitamin B12 deficiency during pregnancy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Biomarkers / blood
Female
Follow-Up Studies
Humans
Postpartum Period / blood*
Pregnancy / blood*
Pregnancy Complications / blood
Transcobalamins / analysis*
Vitamin B 12 / blood*
Vitamin B 12 Deficiency / blood

Substances

Biomarkers
Transcobalamins
Vitamin B 12