Holotranscobalamin remains unchanged during pregnancy. Longitudinal changes of cobalamins and their binding proteins during pregnancy and postpartum

Haematologica. 2007 Dec;92(12):1711-2. doi: 10.3324/haematol.11636.


We confirm a decrease in cobalamins during pregnancy, and report that the active part of cobalamins (holotranscobalamin, holoTC) remains unchanged. The decrease in cobalamins is explained by a decreased holohaptocorrin (holoHC), suggesting that holoTC rather than cobalamins should be used as a marker of vitamin B12 deficiency during pregnancy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Biomarkers / blood
  • Female
  • Follow-Up Studies
  • Humans
  • Postpartum Period / blood*
  • Pregnancy / blood*
  • Pregnancy Complications / blood
  • Transcobalamins / analysis*
  • Vitamin B 12 / blood*
  • Vitamin B 12 Deficiency / blood


  • Biomarkers
  • Transcobalamins
  • Vitamin B 12