A meta-analysis of cognitive remediation in schizophrenia

Am J Psychiatry. 2007 Dec;164(12):1791-802. doi: 10.1176/appi.ajp.2007.07060906.


Objective: This study evaluated the effects of cognitive remediation for improving cognitive performance, symptoms, and psychosocial functioning in schizophrenia.

Method: A meta-analysis was conducted of 26 randomized, controlled trials of cognitive remediation in schizophrenia including 1,151 patients.

Results: Cognitive remediation was associated with significant improvements across all three outcomes, with a medium effect size for cognitive performance (0.41), a slightly lower effect size for psychosocial functioning (0.36), and a small effect size for symptoms (0.28). The effects of cognitive remediation on psychosocial functioning were significantly stronger in studies that provided adjunctive psychiatric rehabilitation than in those that provided cognitive remediation alone.

Conclusions: Cognitive remediation produces moderate improvements in cognitive performance and, when combined with psychiatric rehabilitation, also improves functional outcomes.

Publication types

  • Comparative Study
  • Meta-Analysis
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adaptation, Psychological
  • Adolescent
  • Adult
  • Cognition Disorders / psychology
  • Cognition Disorders / rehabilitation
  • Cognition Disorders / therapy*
  • Cognitive Behavioral Therapy / methods*
  • Employment, Supported
  • Humans
  • Middle Aged
  • Neuropsychological Tests
  • Psychotherapy / methods
  • Randomized Controlled Trials as Topic / statistics & numerical data
  • Rehabilitation, Vocational
  • Schizophrenia / diagnosis
  • Schizophrenia / rehabilitation
  • Schizophrenia / therapy*
  • Schizophrenic Psychology*
  • Social Adjustment
  • Therapy, Computer-Assisted
  • Treatment Outcome