Different strategies for the synthesis of 2'-O-aminoethyl adenosine building blocks

Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):873-7. doi: 10.1080/15257770701505295.

Abstract

The chemical modification of the 2'-O-position of nucleosides proved to be of great importance for the RNA stability. Greater stability of RNA duplexes allows a longer half life in the cell and, therefore, a better effect of RNA Interference. Here we investigated the synthesis of 2'-O-aminoethyl adenosine as a cationic modified building block.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adenosine / chemical synthesis
  • Adenosine / chemistry
  • Molecular Structure
  • RNA / chemical synthesis*
  • RNA / chemistry
  • RNA Stability

Substances

  • RNA
  • Adenosine