Prenatal diagnosis of dumbbell neuroblastoma

Ultrasound Obstet Gynecol. 2008 Jan;31(1):92-5. doi: 10.1002/uog.5148.


A neuroblastoma that develops in the sympathetic nodes can infiltrate the intervertebral foramina and invade the spinal canal, leading to spinal cord and nerve root compression and neurological impairment. Dumbbell neuroblastomas are now considered to be unresectable tumors and preoperative chemotherapy is recommended. We report the prenatal diagnosis of a dumbbell neuroblastoma successfully managed through premature delivery followed by immediate chemotherapy. We suggest that delivering prematurely in such cases is only of benefit if chemotherapy can be administered under favorable conditions. Chemotherapy should proceed immediately after delivery in order to reduce the size of the tumoral mass and its effects on the spine.

Publication types

  • Case Reports

MeSH terms

  • Abortion, Induced / methods
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Cesarean Section
  • Cyclophosphamide / administration & dosage
  • Female
  • Fetal Diseases / diagnosis*
  • Fetal Diseases / drug therapy
  • Fetal Diseases / surgery
  • Humans
  • Infant, Newborn
  • Methylprednisolone / administration & dosage
  • Neuroblastoma / diagnosis*
  • Neuroblastoma / drug therapy
  • Neuroblastoma / surgery
  • Pregnancy
  • Prenatal Diagnosis / methods
  • Spinal Cord Compression / etiology*
  • Spinal Cord Neoplasms / diagnosis*
  • Spinal Cord Neoplasms / drug therapy
  • Spinal Cord Neoplasms / surgery
  • Vincristine / administration & dosage


  • Vincristine
  • Cyclophosphamide
  • Methylprednisolone