Psoriasis is associated with increased beta-defensin genomic copy number

Nat Genet. 2008 Jan;40(1):23-5. doi: 10.1038/ng.2007.48. Epub 2007 Dec 2.


Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Chromosomes, Human, Pair 8
  • Gene Dosage*
  • Genetic Predisposition to Disease
  • Humans
  • Polymorphism, Genetic
  • Polymorphism, Single Nucleotide
  • Psoriasis / genetics*
  • beta-Defensins / genetics*


  • DEFB4A protein, human
  • beta-Defensins