Chlorodifluoromethyl phenyl sulfone: a novel non-ozone-depleting substance-based difluorocarbene reagent for O- and N-difluoromethylations

Chem Commun (Camb). 2007 Dec 28:(48):5149-51. doi: 10.1039/b713156a. Epub 2007 Oct 16.

Abstract

Chlorodifluoromethyl phenyl sulfone, a previously unknown compound that can be readily prepared from non-ODS-based precursors, was found to act as a robust difluorocarbene reagent for O- and N-difluoromethylations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Hydrocarbons, Fluorinated / chemical synthesis*
  • Hydrocarbons, Fluorinated / chemistry*
  • Hydrocarbons, Halogenated / chemical synthesis
  • Hydrocarbons, Halogenated / chemistry*
  • Methylation
  • Molecular Structure
  • Stereoisomerism
  • Sulfones / chemical synthesis
  • Sulfones / chemistry*

Substances

  • Hydrocarbons, Fluorinated
  • Hydrocarbons, Halogenated
  • Sulfones
  • chlorodifluoromethyl phenyl sulfone
  • difluorocarbene