Implicating chromosomal aberrations with meningioma growth and recurrence: results from FISH and MIB-I analysis of grades I and II meningioma tissue

J Neurooncol. 2008 Mar;87(1):43-50. doi: 10.1007/s11060-007-9498-9. Epub 2007 Nov 30.


The fluorescence in situ hybridization (FISH) technique was used in 111 WHO grades I and II meningioma patients. Clinical, radiological, pathological, and immunohistochemical data were compared to aberrations of chromosomes 1p, 14q, and 22q determined by FISH. Significant differences for MIB-1 labeling were found between grades I and II tumors (p < 0.001), and between grade I tumors that recurred and those that did not recur (p < 0.001). Chromosomal aberrations were detected with FISH analysis in nearly 50% of grade I, and in 93% of grade II meningiomas. The numbers of chromosomal aberrations correlated significantly to MIB-1 (p < 0.001), with signs of grossly invasive tumor growth (p < 0.001), and with tumor recurrence (p < 0.01). The findings suggest that adding FISH analysis may allow better prediction of possible meningioma recurrence and may be a useful adjunct for therapy decisions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Cell Proliferation
  • Chromosome Aberrations*
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization, Fluorescence*
  • Ki-67 Antigen / metabolism*
  • Meningeal Neoplasms / genetics*
  • Meningeal Neoplasms / metabolism
  • Meningeal Neoplasms / pathology
  • Meningioma / genetics*
  • Meningioma / metabolism
  • Meningioma / pathology
  • Middle Aged
  • Neoplasm Recurrence, Local / metabolism
  • Neoplasm Recurrence, Local / pathology*
  • Prognosis


  • Ki-67 Antigen