Severe sensorimotor neuropathy after intake of highest dosages of vitamin B6

Neuromuscul Disord. 2008 Feb;18(2):156-8. doi: 10.1016/j.nmd.2007.09.009. Epub 2007 Dec 3.


We illustrate a white caucasian patient with a severe sensorimotor neuropathy due to vitamin B6 hypervitaminosis. The patient used the pendulum to calculate his daily metabolic demands and ingested 9.6g pyridoxine/day. To our knowledge, this is the highest dosage of vitamin B6 administered to humans over prolonged periods of time ever reported in the medical literature. The unique aspect of this case is the muscle weakness and motor findings on electrophysiological testing in what is suggested by the literature to be a pure sensory neuronopathy.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Gait Disorders, Neurologic / chemically induced*
  • Humans
  • Male
  • Peripheral Nervous System Diseases / chemically induced*
  • Self Medication
  • Severity of Illness Index
  • Vitamin B 6 / adverse effects
  • Vitamin B 6 / poisoning*
  • Vitamin B Complex / adverse effects
  • Vitamin B Complex / poisoning*


  • Vitamin B Complex
  • Vitamin B 6