Overexpression of COX-2 and LMP1 are correlated with lymph node in Tunisian NPC patients

Oral Oncol. 2008 Jul;44(7):710-5. doi: 10.1016/j.oraloncology.2007.09.006. Epub 2007 Dec 3.

Abstract

Cyclooxygenase 2 (COX-2) an inducible form of COX is frequently up-regulated in many human tumours. The expression of COX-2 in nasopharyngeal carcinoma (NPC) and its relationship to clinicopathological features were studied in Tunisian patients. COX-2 mRNA was detected in 91% of tumour tissues. Immunohistochemical analysis showed that COX-2 protein was strongly detected in tumour cells and the staining was mainly cytoplasmic. In contrast, COX-2 mRNA and protein were very low or undetectable in normal nasopharyngeal mucosa. Our result showed a significant association of COX-2 overexpression with the lymph node involvement, however, no correlation was observed with age, tumour stage, histological type and distant metastasis. Moreover, we showed that all tumour specimens co-overexpressed COX-2 and the EBV oncoprotein LMP1 corroborating the fact that LPM1 is known to induce COX-2. Altogether, our data suggests that the COX-2 is overexpressed in NPC biopsies and that is linked to the lymph node involvement.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Squamous Cell / metabolism*
  • Child
  • Cyclooxygenase 2 / metabolism*
  • Cytoskeletal Proteins
  • Female
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • LIM Domain Proteins
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Nasopharyngeal Neoplasms / metabolism*
  • Neoplasm Proteins / metabolism*
  • Neoplasm Staging
  • RNA, Messenger / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Up-Regulation
  • Young Adult

Substances

  • Adaptor Proteins, Signal Transducing
  • Cytoskeletal Proteins
  • Intracellular Signaling Peptides and Proteins
  • LIM Domain Proteins
  • Neoplasm Proteins
  • PDLIM7 protein, human
  • RNA, Messenger
  • Cyclooxygenase 2