New phosphatidylserine receptors: clearance of apoptotic cells and more

Dev Cell. 2007 Dec;13(6):759-60. doi: 10.1016/j.devcel.2007.11.009.

Abstract

Phagocytes recognize apoptotic cells using cell surface receptors, and subsequently engulf these cells. In a recent issue of Nature, two papers reported the identification of novel phagocytic receptors that directly interact with apoptotic cell surface phosphatidylserine (PS). The studies provide new insights into the apoptotic cell clearance process and implicate PS receptors in additional signaling events.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Humans
  • Macrophages / physiology*
  • Phagocytosis*
  • Phosphatidylserines / immunology
  • Receptors, Cell Surface / physiology*

Substances

  • Phosphatidylserines
  • Receptors, Cell Surface
  • phosphatidylserine receptor