Synthesis of a 2'-O-(carbomoylmethyl)ribonucleoside H-phosphonate building block and a model dinucleotide

Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1495-9. doi: 10.1080/15257770701542900.

Abstract

In order to obtain higher quality 2'-O-carbamoylmethyl oligoribonucleotides we are conducting studies of this modification. Here we present synthesis of 2'-O-carbamoylmethyl containing H-phosphonate building blocks as well as synthesis of model dinucleotides needed for these studies.

MeSH terms

  • Oligoribonucleotides / chemistry
  • Organophosphonates / chemical synthesis*
  • Organophosphonates / chemistry
  • Ribonucleosides / chemical synthesis
  • Ribonucleosides / chemistry*

Substances

  • 2'-O-(carbomoylmethyl)ribonucleoside H-phosphonate
  • Oligoribonucleotides
  • Organophosphonates
  • Ribonucleosides