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. 2007;26(6-7):625-8.
doi: 10.1080/15257770701490431.

Novel Non-Nucleoside Human Cytomegalovirus Inhibitors Based Upon TSAO Nucleoside Derivatives: Structure-Activity Relationships

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Novel Non-Nucleoside Human Cytomegalovirus Inhibitors Based Upon TSAO Nucleoside Derivatives: Structure-Activity Relationships

Sonia de Castro et al. Nucleosides Nucleotides Nucleic Acids. .

Abstract

TSAO derivatives are a unique group of potent and highly specific inhibitors of HIV-1 replication. We have recently reported 4''-ureido TSAO derivatives that are devoid of anti-HIV-1 activity, but inhibit human cytomegalovirus with an activity comparable to that of Ganciclovir. We herein report the synthesis and biological evaluation of novel 4''-ureido TSAO derivatives in order to evaluate the structural features required for anti-HCMV activity. Interestingly, these studies revealed that the compounds may inhibit HCMV at the DNA polymerase step via a non-nucleoside mechanism.

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