Regulatory T cells and tumour immunity - observations in mice and men

Immunology. 2008 Feb;123(2):157-63. doi: 10.1111/j.1365-2567.2007.02748.x. Epub 2007 Dec 7.


An enormous body of work supports a role for CD4+ CD25+ regulatory cells (Tregs) in shaping the immune response to tumours. Indeed, there is evidence that the cells impede effective tumour immunosurveillance, inhibit vaccine-induced antitumour immune responses and promote tumour progression. Studies exploring the impact of Tregs on tumour development are discussed in the context of manipulating this T-cell population for the purpose of cancer immunotherapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Forkhead Transcription Factors / blood
  • Humans
  • Immune Tolerance
  • Immunotherapy / methods
  • Mice
  • Neoplasms / immunology*
  • Neoplasms / pathology
  • Neoplasms / therapy
  • Neoplasms, Experimental / immunology
  • T-Lymphocytes, Regulatory / immunology*


  • Forkhead Transcription Factors
  • Foxp3 protein, mouse