Abstract
Four polyketides, leptosphaerone C (1), penicillenone (2), arugosin I (3) and 9-demethyl FR-901235 (4), as well as five known compounds, bacillosporin A (5), bacillosporin C (6), sequoiamonascin D (7), sequoiatone A (8), and sequoiatone B (9) were isolated from the Penicillium sp. JP-1, an endophytic fungus isolated from Aegiceras corniculatum. Their structures were determined by spectroscopic methods, mainly by 2D NMR spectroscopic analyses. Compound 1 showed cytotoxicity against A-549 cells with an IC50 value of 1.45 microM, while compound 2 showed cytotoxicity against P388 cells with an IC50 value of 1.38 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cyclohexanones / chemistry*
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Cyclohexanones / isolation & purification
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Cyclohexanones / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Macrolides / chemistry*
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Macrolides / isolation & purification
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Macrolides / pharmacology
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Magnetic Resonance Spectroscopy / methods
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Magnetic Resonance Spectroscopy / standards
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Mice
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Molecular Conformation
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Penicillium / chemistry*
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Penicillium / isolation & purification
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Phenalenes / chemistry*
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Phenalenes / isolation & purification
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Phenalenes / pharmacology
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Phenols / chemistry*
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Phenols / isolation & purification
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Phenols / pharmacology
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Primulaceae / microbiology*
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Reference Standards
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Stereoisomerism
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Structure-Activity Relationship
Substances
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9-demethyl FR-901235
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Cyclohexanones
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Macrolides
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Phenalenes
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Phenols
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arugosin I
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leptosphaerone C
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penicillenone