Polyketides from Penicillium sp. JP-1, an endophytic fungus associated with the mangrove plant Aegiceras corniculatum

Phytochemistry. 2008 Mar;69(5):1273-8. doi: 10.1016/j.phytochem.2007.10.030. Epub 2007 Dec 11.

Abstract

Four polyketides, leptosphaerone C (1), penicillenone (2), arugosin I (3) and 9-demethyl FR-901235 (4), as well as five known compounds, bacillosporin A (5), bacillosporin C (6), sequoiamonascin D (7), sequoiatone A (8), and sequoiatone B (9) were isolated from the Penicillium sp. JP-1, an endophytic fungus isolated from Aegiceras corniculatum. Their structures were determined by spectroscopic methods, mainly by 2D NMR spectroscopic analyses. Compound 1 showed cytotoxicity against A-549 cells with an IC50 value of 1.45 microM, while compound 2 showed cytotoxicity against P388 cells with an IC50 value of 1.38 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cyclohexanones / chemistry*
  • Cyclohexanones / isolation & purification
  • Cyclohexanones / pharmacology
  • Drug Screening Assays, Antitumor
  • Humans
  • Macrolides / chemistry*
  • Macrolides / isolation & purification
  • Macrolides / pharmacology
  • Magnetic Resonance Spectroscopy / methods
  • Magnetic Resonance Spectroscopy / standards
  • Mice
  • Molecular Conformation
  • Penicillium / chemistry*
  • Penicillium / isolation & purification
  • Phenalenes / chemistry*
  • Phenalenes / isolation & purification
  • Phenalenes / pharmacology
  • Phenols / chemistry*
  • Phenols / isolation & purification
  • Phenols / pharmacology
  • Primulaceae / microbiology*
  • Reference Standards
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • 9-demethyl FR-901235
  • Cyclohexanones
  • Macrolides
  • Phenalenes
  • Phenols
  • arugosin I
  • leptosphaerone C
  • penicillenone