[Multicenter study of the risk of infection in diabetics. I. Correlation between altered glucose metabolism and cutaneous reactivity to the Multitest IMC]

Minerva Endocrinol. Jul-Sep 1991;16(3):119-25.
[Article in Italian]


Within the framework of a multicentre study on the risk of infection in diabetes, organised to document the frequency of subjects predisposed to infoffion among the diabetic population and to evaluate the effects of Thymostimulin on the latter, 176 subjects (38%) with a deficient response (less than or equal to alarm score), of which 82 (18%) were totally anergic, were selected from a population of 460 diabetic subjects, both type I and type II, using the Multitest IMC multiantigenic delayed hypersensitivity test. It was not possible to establish any relationship between altered skin response and age, whereas males appeared to be more predisposed than females. The degree of metabolic compensation also influenced the degree of skin response, although this was not decisive. Hypergic and anergic responses were more frequent in type I diabetic subjects than in type II subjects, probably due to the greater immunological involvement of this type of diabetes.

Publication types

  • Comparative Study
  • Multicenter Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Blood Glucose / analysis*
  • Diabetes Mellitus, Type 1 / immunology*
  • Diabetes Mellitus, Type 2 / immunology*
  • Disease Susceptibility / immunology
  • Female
  • Fructosamine
  • Glycated Hemoglobin A / analysis
  • Hexosamines / blood
  • Humans
  • Hypersensitivity, Delayed / immunology
  • Immunity, Cellular*
  • Infections / etiology*
  • Intradermal Tests
  • Male
  • Middle Aged
  • Risk


  • Blood Glucose
  • Glycated Hemoglobin A
  • Hexosamines
  • Fructosamine