Microwave-assisted synthesis and antimicrobial activities of flavonoid derivatives

Sherif B Abdel Ghani; Louise Weaver; Zidan H Zidan; Hussein M Ali; C William Keevil; Richard C D Brown

doi:10.1016/j.bmcl.2007.11.081

Microwave-assisted synthesis and antimicrobial activities of flavonoid derivatives

Bioorg Med Chem Lett. 2008 Jan 15;18(2):518-22. doi: 10.1016/j.bmcl.2007.11.081. Epub 2007 Nov 28.

Authors

Sherif B Abdel Ghani¹, Louise Weaver, Zidan H Zidan, Hussein M Ali, C William Keevil, Richard C D Brown

Affiliation

¹ School of Chemistry, University of Southampton, Southampton SO17 1BJ, UK.

PMID: 18068365
DOI: 10.1016/j.bmcl.2007.11.081

Abstract

Eleven flavonoid derivatives were synthesised using a modified Baker-Venkataraman rearrangement, and subsequent microwave-assisted closure of the heterocyclic ring. All of the synthetic compounds displayed antifungal activity against Aspergillus niger and Fusarium oxysporium, and two of the synthetic flavonoid analogues exhibited significant activity against methicillin-resistant Staphylococcus aureus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / chemical synthesis*
Anti-Infective Agents / pharmacology*
Aspergillus niger / drug effects
Flavonoids / chemical synthesis*
Flavonoids / pharmacology*
Fusarium / drug effects
Methicillin Resistance
Microbial Sensitivity Tests
Microwaves*
Staphylococcus aureus / drug effects

Substances

Anti-Infective Agents
Flavonoids