Type I interferon as a stimulus for cross-priming

Cytokine Growth Factor Rev. 2008 Feb;19(1):33-40. doi: 10.1016/j.cytogfr.2007.10.007.

Abstract

Type I interferon (IFN-alpha/beta) is induced rapidly by infection and is well recognised for its crucial role in innate defence. However, it is evident that IFN-alpha/beta also serves as a signal for the generation of adaptive immune responses. In this review, we focus on the involvement of IFN-alpha/beta in the induction of CD8+ T cell responses by cross-priming.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antigen Presentation / physiology
  • CD8-Positive T-Lymphocytes / immunology*
  • Cross-Priming / physiology*
  • Dendritic Cells / immunology
  • Humans
  • Interferon Type I / biosynthesis
  • Interferon Type I / physiology*
  • Receptor, Interferon alpha-beta / physiology

Substances

  • Interferon Type I
  • Receptor, Interferon alpha-beta