Characterization of a novel congenic strain of diabetic fatty (WBN/Kob-Lepr(fa)) rat

Biochem Biophys Res Commun. 2008 Feb 8;366(2):556-62. doi: 10.1016/j.bbrc.2007.12.003. Epub 2007 Dec 7.


The WBN/Kob-Lepr(fa) rat is a new congenic strain for the fa allele of the leptin receptor gene (Lepr). Homozygous (fa/fa) WBN/Kob-Lepr(fa) rats provide a model of non-insulin-dependent diabetes with obesity. Here, we describe the characteristics of this new animal model in detail. At 7 weeks of age, both male and female obese WBN/Kob rats showed inflammatory cell infiltration of the pancreas that suggested pan-pancreatitis and an abnormal OGTT. At 3 months of age, both male and female obese WBN/Kob rats developed overt diabetes mellitus associated with severe chronic pancreatitis. In contrast, lean female WBN/Kob rats do not develop pancreatitis or diabetes. In WBN/Kob rats, this mutation might promote the onset of severe pancreatitis, leading to the rapid development of diabetes mellitus.

MeSH terms

  • Animals
  • Animals, Congenic
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Disease Models, Animal*
  • Leptin / genetics
  • Leptin / metabolism*
  • Obesity / physiopathology*
  • Pancreatitis / pathology*
  • Rats
  • Receptors, Leptin / genetics
  • Receptors, Leptin / metabolism*


  • Leptin
  • Receptors, Leptin