Thymic output and peripheral T lymphocyte subsets in relapsing--remitting multiple sclerosis patients treated or not by IFN-beta

J Neuroimmunol. 2008 Jan;193(1-2):188-94. doi: 10.1016/j.jneuroim.2007.10.027.


We explored the parameters of central and peripheral tolerance in patients with stable relapsing-remitting multiple sclerosis, treated or not with IFN-beta. TREC-positive T cells were lower in patients compared with controls, mainly in CD4+ subset, compatible with a thymus dysfunction or an expansion of peripheral lymphocytes. Compared to controls, the frequency of activated CD4+CD25+ T cells was higher in patients without modification of the CD4+CD25(high) T cell proportion. The IFN-beta-treatment did not modify the TREC-positive cell frequency nor the naive/memory T cell subset percentage but was associated with lower blood lymphocyte count and a lower frequency of CD4+CD45RC(high) subset.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Humans
  • Interferon-beta / therapeutic use*
  • Leukocyte Common Antigens / analysis
  • Lymphocyte Culture Test, Mixed
  • Male
  • Middle Aged
  • Multiple Sclerosis, Relapsing-Remitting / drug therapy
  • Multiple Sclerosis, Relapsing-Remitting / immunology*
  • Protein Isoforms
  • T-Lymphocyte Subsets / immunology*
  • Thymus Gland / immunology*


  • Protein Isoforms
  • Interferon-beta
  • Leukocyte Common Antigens