Colloidal silver fabrication using the spark discharge system and its antimicrobial effect on Staphylococcus aureus

Med Eng Phys. 2008 Oct;30(8):948-52. doi: 10.1016/j.medengphy.2007.10.007. Epub 2008 Feb 20.


Nanoscale techniques for silver production may assist the resurgence of the medical use of silver, especially given that pathogens are showing increasing resistance to antibiotics. Traditional chemical synthesis methods for colloidal silver (CS) may lead to the presence of toxic chemical species or chemical residues, which may inhibit the effectiveness of CS as an antibacterial agent. To counter these problems a spark discharge system (SDS) was used to fabricate a suspension of colloidal silver in deionized water with no added chemical surfactants. SDS-CS contains both metallic silver nanoparticles (Ag(0)) and ionic silver forms (Ag(+)). The antimicrobial affect of SDS-CS on Staphylococcus aureus was studied. The results show that CS solutions with an ionic silver concentration of 30 ppm or higher are strong enough to destroy S. aureus. In addition, it was found that a solution's antimicrobial potency is directly related to its level of silver ion concentration.

MeSH terms

  • Anti-Infective Agents / administration & dosage*
  • Anti-Infective Agents / chemical synthesis*
  • Cell Survival / drug effects
  • Colloids / administration & dosage
  • Colloids / chemical synthesis
  • Electrochemistry / methods
  • Hot Temperature
  • Nanostructures / administration & dosage*
  • Nanostructures / chemistry
  • Nanostructures / ultrastructure
  • Particle Size
  • Silver / administration & dosage*
  • Silver / chemistry*
  • Staphylococcus aureus / cytology*
  • Staphylococcus aureus / drug effects*


  • Anti-Infective Agents
  • Colloids
  • Silver