The macroPARP genes Parp-9 and Parp-14 are developmentally and differentially regulated in mouse tissues

Dev Dyn. 2008 Jan;237(1):209-15. doi: 10.1002/dvdy.21399.


The macroPARPs Parp-9 and Parp-14 are macro domain containing poly(ADP-ribose) polymerases involved in transcriptional regulation in response to immunoregulatory cytokines. Their genes reside in the same locus (16B3), and the Parp-9 gene lies head-to-head and shares its promoter with the gene encoding its partner, Bbap. Here, we provide a detailed analysis of Parp-9, Parp-14, and Bbap expression during mouse development and adulthood. Parp-9 is developmentally regulated, and prominently expressed in the thymus and specific regions of the brain and gut. In adults, highest expression is maintained in the thymus and intestine. Parp-14 is more weakly expressed, mainly in the thymus during development and in adulthood. In addition, we show that Bbap is essentially coexpressed with Parp-9 during development and in adult mouse. However, the different levels of their transcripts detected in the developing brain and gut suggest that Bbap and Parp-9 display both common and independent tissue-specific regulations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / embryology
  • Brain / enzymology
  • Brain / metabolism
  • Female
  • Gene Expression Profiling*
  • Gene Expression Regulation, Developmental*
  • Gene Expression Regulation, Enzymologic*
  • In Situ Hybridization
  • Intestinal Mucosa / metabolism
  • Intestines / embryology
  • Intestines / enzymology
  • Isoenzymes / genetics
  • Mice
  • Poly(ADP-ribose) Polymerases / genetics*
  • Pregnancy
  • Thymus Gland / embryology
  • Thymus Gland / enzymology
  • Thymus Gland / metabolism


  • Isoenzymes
  • Parp14 protein, mouse
  • Parp9 protein, mouse
  • Poly(ADP-ribose) Polymerases