The multidisciplinary management of gastrointestinal cancer. The use of molecular markers in the diagnosis and treatment of colorectal cancer

Sabine Tejpar

doi:10.1016/j.bpg.2007.10.002

The multidisciplinary management of gastrointestinal cancer. The use of molecular markers in the diagnosis and treatment of colorectal cancer

Best Pract Res Clin Gastroenterol. 2007;21(6):1071-87. doi: 10.1016/j.bpg.2007.10.002.

Author

Sabine Tejpar¹

Affiliation

¹ Digestive Oncology Unit, Centre for Human Genetics, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium. sabine.tejpar@uz.kuleuven.ac.be

PMID: 18070704
DOI: 10.1016/j.bpg.2007.10.002

Abstract

Rapidly growing insights into the molecular biology of colorectal cancer led to high hopes for the identification of molecular markers to be used in optimised and tailored treatment regimens for this disorder. However, no molecular marker has yet made it into daily practice. In this review we will discuss some of the potential molecular markers, focus on the lessons learnt from marker development and identify strategies for the future.

Publication types

Review

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Biomarkers, Tumor / analysis*
Biomarkers, Tumor / genetics
Chemotherapy, Adjuvant
Colectomy
Colorectal Neoplasms / chemistry*
Colorectal Neoplasms / diagnosis
Colorectal Neoplasms / genetics
Colorectal Neoplasms / pathology
Colorectal Neoplasms / therapy
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Neoplasm Metastasis
Patient Selection*
Pharmacogenetics
Prognosis
Radiotherapy, Adjuvant
Reproducibility of Results

Substances

Biomarkers, Tumor