Multiple kinases and system robustness: a link between Cdc37 and genome integrity

Cell Cycle. 2007 Dec 15;6(24):3145-7. doi: 10.4161/cc.6.24.5147. Epub 2007 Oct 3.


We identified 38 genes as having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37, using a genome-wide synthetic screening approach. The identified genes included a sub-network of highly interacting genes enriched for functions in genome integrity and comprising multiple components of several discrete molecular machines. A network analysis approach related these machines to a small group of cell cycle checkpoint kinases.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism*
  • Genomic Instability*
  • Molecular Chaperones / genetics
  • Molecular Chaperones / metabolism*
  • Mutation
  • Phosphotransferases / metabolism*
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism*


  • CDC37 protein, S cerevisiae
  • Cell Cycle Proteins
  • Molecular Chaperones
  • Saccharomyces cerevisiae Proteins
  • Phosphotransferases