Convection-enhanced delivery for treatment of brain tumors

Expert Rev Anticancer Ther. 2007 Dec;7(12 Suppl):S79-85. doi: 10.1586/14737140.7.12s.S79.

Abstract

Recently, innovative therapies have been developed for the treatment of malignant gliomas. Unfortunately, adequate delivery of these therapies has been a major obstacle to clinical success. Intravenous administration is restricted by the presence of the blood-brain barrier while local delivery, such as with drug-impregnated wafers, results in limited parenchyma penetration. Convection-enhanced delivery is a promising method for the delivery of macromolecules to the CNS. Convection-enhanced delivery involves the infusion of therapeutic agents via surgically implanted catheters and uses a pressure gradient to achieve a greater volume of distribution compared with that seen with diffusion alone. This article will review the development of convection-enhanced delivery and its use in the treatment of malignant gliomas.

Publication types

  • Review

MeSH terms

  • Adult
  • Animals
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / mortality
  • Brain Neoplasms / pathology
  • Chemotherapy, Cancer, Regional Perfusion / methods*
  • Clinical Trials as Topic
  • Convection
  • Disease Models, Animal
  • Female
  • Glioma / drug therapy*
  • Glioma / mortality
  • Glioma / pathology
  • Humans
  • Infusion Pumps, Implantable*
  • Male
  • Prognosis
  • Rats
  • Risk Assessment
  • Sensitivity and Specificity
  • Survival Analysis
  • Treatment Outcome