Severe deterioration of psoriasis due to an insulinoma

Clin Exp Dermatol. 2008 Mar;33(2):145-7. doi: 10.1111/j.1365-2230.2007.02578.x. Epub 2007 Dec 10.


We report a case of a 56-year-old woman who presented with a severe exacerbation of psoriasis with concurrent hypoglycaemic episodes. Methotrexate 17.5 mg weekly was required to control her psoriasis. Investigation of her hypoglycaemia showed raised levels of insulin, C-peptide and proinsulin. Radiological investigation showed a tumour at the tail of the pancreas and the diagnosis was insulinoma. A spleen-preserving distal pancreatectomy was performed and the hypoglycaemic symptoms resolved. Immediately following the pancreatectomy, methotrexate was stopped and the patient's psoriasis went into remission. During a 2-year follow-up, she has required only minimal topical treatment for her skin.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Humans
  • Hypoglycemia / etiology*
  • Insulinoma / complications*
  • Insulinoma / surgery
  • Middle Aged
  • Pancreatectomy / methods
  • Pancreatic Hormones / metabolism
  • Psoriasis / drug therapy
  • Psoriasis / etiology*
  • Treatment Outcome


  • Pancreatic Hormones