[Effect of nooglutyl on the behavior and memory of SAMP10 mice with genetically determined accelerated aging]

Eksp Klin Farmakol. Jul-Aug 2007;70(4):3-6.
[Article in Russian]

Abstract

It is established that SAMP10 mice (senescence-accelerated mice prone 10) with genetically determined accelerated senescence at an age of 9-month exhibit (in comparison to 3-month animals of the same strain) the behavior and memory deficits typical of aged animals, namely, reduced locomotor activity elevated anxiety, and disturbances of memory trace retrieval. Nooglutyl in a dose of 20 mg/kg produces a positive effect on the behavior and memory of 9-month old SAMP10 mice. The observed improvements include optimization of the locomotor activity in the open field test, diminished anxiety in elevated plus maze test, and improved retrieval of passive avoidance reflex.

MeSH terms

  • Aging, Premature / genetics*
  • Animals
  • Behavior, Animal / drug effects*
  • Glutamates / pharmacology*
  • Male
  • Maze Learning / drug effects
  • Memory / drug effects*
  • Mice
  • Mice, Mutant Strains
  • Nicotinic Acids / pharmacology*

Substances

  • Glutamates
  • Nicotinic Acids
  • nooglutil