Tris(2,4,6-trimethoxyphenyl)methyl carbenium ion for charge derivatization of amines and amino acids

J Mass Spectrom. 2008 May;43(5):623-7. doi: 10.1002/jms.1360.

Abstract

Primary and secondary alkyl amines substitute readily one of the para-methoxy substituents of tris(2,4,6-trimethoxyphenyl)methyl carbenium ion. With this rapid process, the preparation of permanently charged positive derivatives of amines, amino acids and small C-protected peptides is achieved. This is utilized here to facilitate the matrix assisted laser desorption ionization-time-of-flight (MALDI-TOF) analysis of these compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry*
  • Amino Acids / chemistry*
  • Electrochemistry / methods*
  • Ions
  • Methane / analogs & derivatives*
  • Methane / chemistry
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods*
  • Static Electricity

Substances

  • Amines
  • Amino Acids
  • Ions
  • carbene
  • Methane