"JIP"ing along the axon: the complex roles of JIPs in axonal transport

Bioessays. 2008 Jan;30(1):10-4. doi: 10.1002/bies.20695.


JIPs are JNK interacting proteins and bind to JNK cascade kinases. JIP1 and JIP3 were known to be adaptors linking cargo to Kinesin-I, a major molecular motor for axonal transport. Recent research sheds further light on JIPs' complex roles in axonal transport, namely in activation of Kinesin-I and in cargo release. In Drosophila, APLIP1/JIP1 allows the Kinesin-I complex to enable cargo release through activation of JNK signaling.1 In mammalian cell culture, JIP1 is necessary and, together with UNC-76/FEZ1, sufficient for activating Kinesin-I.2 I discuss and compare the many roles played by JIP1 and JIP3 through interactions with several distinct players, in retrograde as well as anterograde transport.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism
  • Adaptor Proteins, Signal Transducing / physiology*
  • Animals
  • Axonal Transport / physiology*
  • Carrier Proteins / metabolism
  • Carrier Proteins / physiology
  • Drosophila Proteins / metabolism
  • Drosophila Proteins / physiology
  • Humans
  • Kinesins / metabolism
  • Models, Biological
  • Multigene Family / physiology
  • Nerve Tissue Proteins / metabolism
  • Nerve Tissue Proteins / physiology


  • APP-like protein interacting protein 1, Drosophila
  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • Drosophila Proteins
  • MAPK8IP1 protein, human
  • MAPK8IP3 protein, human
  • Nerve Tissue Proteins
  • Khc protein, Drosophila
  • Kinesins