Pancreatic endocrine and exocrine changes in celiac disease

World J Gastroenterol. 2007 Dec 21;13(47):6344-6. doi: 10.3748/wjg.v13.i47.6344.


Although there is a great deal of information on celiac disease and associated involvement of other non-intestinal sites, data on concomitant changes in the structure and function of the pancreas is limited. The present review critically examines pancreatic endocrine changes that have been well documented in the literature, including insulin-dependent diabetes mellitus. Pancreatic exocrine alterations may also occur, and if severe, marked malnutrition with pancreatic failure and ductal calcification have been observed. Finally, other pancreatic disorders have been recorded with celiac disease.

Publication types

  • Review

MeSH terms

  • Celiac Disease / complications*
  • Celiac Disease / physiopathology
  • Humans
  • Islets of Langerhans / physiopathology*
  • Pancreas, Exocrine / physiopathology*
  • Pancreatic Diseases / etiology
  • Pancreatic Diseases / physiopathology*