Abstract
Two new morphinane alkaloid dimers, 2,2'-disinomenine (1) and 7',8'-dihydro-1,1'-disinomenine (2), and known 1, 1'-disinomenine (3), were isolated from ethanol extracts of stems of Sinomenium acutum. Their structures were elucidated on the basis of spectroscopic methods. The absolute configuration of alkaloids 1-3 was determined by direct comparison of their CD spectra with the known alkaloid sinomenine. The isolated alkaloids were tested for cytotoxicity against A549, P388, and HeLa cell lines, and 1 and 3 showed weak inhibition against A549 and Hela cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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HeLa Cells
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Humans
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Molecular Structure
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Morphinans / chemistry
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Morphinans / isolation & purification*
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Morphinans / pharmacology
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Plant Stems / chemistry
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Plants, Medicinal / chemistry*
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Sinomenium / chemistry*
Substances
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2,2'-disinomenine
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7',8'-dihydro-1,1'-disinomenine
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Morphinans
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sinomenine