Neonatal necrotising fasciitis--Varanasi experience

Int Wound J. 2008 Mar;5(1):108-12. doi: 10.1111/j.1742-481X.2007.00350.x. Epub 2007 Dec 12.

Abstract

Neonatal necrotising fasciitis (NNF) is a rare and fatal disorder. Successful outcome depends on timely intervention. This paper presents single-centre experience of presentation, management and outcome of the condition. Fifteen patients of NNF were managed during the study period of 5 years. Parameters studied were age, sex, site of involvement and treatment. Treatment included intravenous (i.v.) antibiotics and conservative surgery. Age of presentation was 10-28 days. Male to female ratio was 2:1. Neck and scalp were the commonest site (53.3%). Culture reports were unimicrobial in 66% with predominance of Staphylococcus species. Predisposing factors included rural environment (100%), malnourishment (60%), boils (40%) and scratch injury (13%). Forty per cent had idiopathic NNF. Wound healing was by secondary intention in 46.6% and skin grafting in 53.3%. Overall survival was 80%, while the premature had poorer outcome. NNF is a serious disorder. Early treatment with i.v. antibiotics and supportive measures followed by debridement improves survival.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Bandages
  • Cohort Studies
  • Debridement
  • Fasciitis, Necrotizing / etiology
  • Fasciitis, Necrotizing / mortality
  • Fasciitis, Necrotizing / therapy*
  • Female
  • Humans
  • India
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / etiology
  • Infant, Premature, Diseases / mortality
  • Infant, Premature, Diseases / therapy*
  • Male
  • Retrospective Studies
  • Risk Factors
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents