M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis

FEMS Immunol Med Microbiol. 2008 Jan;52(1):2-12. doi: 10.1111/j.1574-695X.2007.00359.x. Epub 2007 Dec 10.

Abstract

M-cells are specialized cells found in the follicle-associated epithelium of intestinal Peyer's patches of gut-associated lymphoid tissue and in isolated lymphoid follicles, appendix and in mucosal-associated lymphoid tissue sites outside the gastrointestinal tract. In the gastrointestinal tract, M-cells play an important role in transport of antigen from the lumen of the small intestine to mucosal lymphoid tissues, where processing and initiation of immune responses occur. Thus, M-cells act as gateways to the mucosal immune system and this function has been exploited by many invading pathogens. Understanding the mechanism by which M-cells sample antigen will inform the design of oral vaccines with improved efficacy in priming mucosal and systemic immune responses. In this review, the origin and morphology of M-cells, and their role in mucosal immunity and pathogenesis of infections are discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Immunity, Mucosal*
  • Intestinal Mucosa / immunology*
  • Peyer's Patches / cytology*
  • Peyer's Patches / immunology*