The age of crosstalk: phosphorylation, ubiquitination, and beyond

Mol Cell. 2007 Dec 14;28(5):730-8. doi: 10.1016/j.molcel.2007.11.019.

Abstract

Crosstalk between different types of posttranslational modification is an emerging theme in eukaryotic biology. Particularly prominent are the multiple connections between phosphorylation and ubiquitination, which act either positively or negatively in both directions to regulate these processes.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Humans
  • Models, Biological
  • Phosphorylation
  • Proteasome Endopeptidase Complex / metabolism
  • Protein Processing, Post-Translational*
  • Ubiquitin / metabolism
  • Ubiquitin-Conjugating Enzymes / metabolism
  • Ubiquitination*

Substances

  • Ubiquitin
  • Ubiquitin-Conjugating Enzymes
  • Proteasome Endopeptidase Complex