A seminal finding for understanding HIV transmission

Cell. 2007 Dec 14;131(6):1044-6. doi: 10.1016/j.cell.2007.11.030.


Although the worldwide incidence of HIV infection is high, the retrovirus displays a surprisingly low infectivity in vitro. As a potential explanation for this discrepancy, Münch et al. (2007) now identify and characterize a factor found in human semen that under certain conditions can enhance HIV infectivity by more than 100,000-fold.

Publication types

  • Comment

MeSH terms

  • Acid Phosphatase
  • Amyloid / physiology*
  • HIV Infections / transmission*
  • Humans
  • Peptide Fragments / physiology
  • Protein Tyrosine Phosphatases / chemistry*
  • Semen / metabolism*
  • Semen / physiology
  • Sexually Transmitted Diseases, Viral
  • Viral Load


  • Amyloid
  • Peptide Fragments
  • Acid Phosphatase
  • prostatic acid phosphatase
  • Protein Tyrosine Phosphatases