Calcium signaling

Cell. 2007 Dec 14;131(6):1047-58. doi: 10.1016/j.cell.2007.11.028.


Calcium ions (Ca(2+)) impact nearly every aspect of cellular life. This review examines the principles of Ca(2+) signaling, from changes in protein conformations driven by Ca(2+) to the mechanisms that control Ca(2+) levels in the cytoplasm and organelles. Also discussed is the highly localized nature of Ca(2+)-mediated signal transduction and its specific roles in excitability, exocytosis, motility, apoptosis, and transcription.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium Signaling*
  • Calcium-Binding Proteins / metabolism
  • Calcium-Transporting ATPases / metabolism
  • Calmodulin / metabolism
  • Cell Membrane / metabolism
  • Cell Movement
  • Humans
  • Models, Molecular
  • Signal Transduction*


  • Calcium-Binding Proteins
  • Calmodulin
  • Calcium-Transporting ATPases