What does serum fibroblast growth factor 23 do in hemodialysis patients?

Kidney Int. 2008 Jan;73(1):3-5. doi: 10.1038/sj.ki.5002651.


Fibroblast growth factor 23 (FGF-23) is a phosphate-regulating substance largely produced by osteocytes. Its major action, in normal subjects, is the inhibition of Na-coupled reabsorption of inorganic phosphate in the renal proximal tubule. FGF-23 levels increase markedly in dialysis patients. Why do the FGF-23 levels increase in these patients, and do they have any physiologic or pathophysiologic effects?

Publication types

  • Comment

MeSH terms

  • Fibroblast Growth Factor-23
  • Fibroblast Growth Factors / blood*
  • Fibroblast Growth Factors / metabolism
  • Humans
  • Kidney Tubules / metabolism*
  • Phosphates / metabolism
  • Renal Dialysis*


  • FGF23 protein, human
  • Phosphates
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23