Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis

Nat Genet. 2008 Jan;40(1):29-31. doi: 10.1038/ng.2007.52. Epub 2007 Dec 16.


We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyotrophic Lateral Sclerosis / genetics*
  • Case-Control Studies
  • Chromosomes, Human, Pair 7
  • Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
  • Genetic Predisposition to Disease*
  • Humans
  • Nerve Tissue Proteins / genetics*
  • Peptide Hydrolases / genetics*
  • Polymorphism, Single Nucleotide
  • Potassium Channels / genetics*
  • White People / genetics


  • Nerve Tissue Proteins
  • Potassium Channels
  • DPP6 protein, human
  • Peptide Hydrolases
  • Dipeptidyl-Peptidases and Tripeptidyl-Peptidases