Aspartame bioassay findings portend human cancer hazards

Int J Occup Environ Health. Oct-Dec 2007;13(4):446-8. doi: 10.1179/oeh.2007.13.4.446.


The U.S. Food and Drug Administration (FDA) should reevaluate its position on aspartame as being safe under all conditions. Animal bioassay results predict human cancer risks, and a recent animal study confirms that there is a potential aspartame risk to humans. Aspartame is produced and packaged in China for domestic use and global distribution. Japan, France, and the United States are also major producers. No study of long-term adverse occupational health effects on aspartame workers have been conducted. The FDA should consider sponsoring a prospective epidemiologic study of aspartame workers.

Publication types

  • Editorial

MeSH terms

  • Animals
  • Aspartame / adverse effects*
  • Aspartame / standards
  • Biological Assay
  • Carcinogenicity Tests
  • Humans
  • Neoplasms / chemically induced*
  • Occupational Exposure
  • Occupational Health
  • Sweetening Agents / adverse effects*
  • Sweetening Agents / standards
  • United States
  • United States Food and Drug Administration / standards


  • Sweetening Agents
  • Aspartame