4-methylquinazoline is a minor component of the male sex pheromone in Nasonia vitripennis

J Chem Ecol. 2008 Jan;34(1):99-102. doi: 10.1007/s10886-007-9411-1. Epub 2007 Dec 18.


We identified 4-methylquinazoline (4-MeQ) as a minor component of the male sex pheromone of the parasitoid Nasonia vitripennis. Like the major components (4R,5R)- and (4R,5S)-5-hydroxy-4-decanolide (HDL), 4-MeQ is synthesized in the abdomen of males. At doses of 6 or 1 ng, 4-MeQ synergized the response of virgin females to the HDL-diastereomers in a still-air olfactometer, but was not attractive as a single component. 4-MeQ is also responsible for the characteristic medicinal odor of N. vitripennis males.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Female
  • Lactones / analysis
  • Lactones / pharmacology*
  • Male
  • Odorants
  • Quinazolines / analysis*
  • Quinazolines / pharmacology*
  • Sex Attractants / analysis*
  • Sex Attractants / pharmacology*
  • Sexual Behavior, Animal / drug effects*
  • Wasps / drug effects
  • Wasps / physiology*


  • Lactones
  • Quinazolines
  • Sex Attractants