The cognitive enhancer T-588 partially compensates the motor associative learning impairments induced by scopolamine injection in mice

Behav Neurosci. 2007 Dec;121(6):1203-14. doi: 10.1037/0735-7044.121.6.1203.

Abstract

The authors studied the effects of T-588 on scopolamine-induced memory impairments in the acquisition of a classical eyeblink conditioning in behaving adult mice. Mice injected with 0.3 mg/kg of scopolamine showed a marked deficit, compared with nontreated mice, in the acquisition of classical eyeblink conditioning using a trace paradigm. Coadministration of T-588 (0.05% wt/vol, in water) with scopolamine (0.3 mg/kg) significantly prevented this deficit in associative learning. To further assess the effects of T-588 on motor coordination and the cognitive deficits induced by scopolamine, the authors compared adult controls or scopolamine-treated mice in different behavioral tasks: rotarod, object recognition, passive avoidance, and prepulse inhibition. In all of these tasks, the authors found a significant impairment in the motor or cognitive abilities in scopolamine-injected mice, compared with controls. In addition, the coadministration of T-588 with scopolamine restored deficits induced by scopolamine alone. Importantly, the administration of T-588 alone did not evoke any change compared with values obtained for controls. These results suggest that T-588 could be used as a pharmacological agent to improve motor and associative learning disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation / methods
  • Analysis of Variance
  • Animals
  • Association Learning / drug effects*
  • Avoidance Learning / drug effects
  • Behavior, Animal / drug effects
  • Conditioning, Eyelid / drug effects
  • Diethylamines / therapeutic use*
  • Drug Interactions
  • Electromyography
  • Inhibition, Psychological
  • Learning Disabilities / chemically induced
  • Learning Disabilities / drug therapy*
  • Male
  • Mice
  • Motor Activity / drug effects*
  • Psychomotor Performance / drug effects*
  • Reaction Time / drug effects
  • Recognition, Psychology / drug effects
  • Scopolamine
  • Thiophenes / therapeutic use*
  • Time Factors

Substances

  • Diethylamines
  • Thiophenes
  • T 588
  • Scopolamine