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Review
, 9 (2), 152-6

Research Ethics and the Challenge of Whole-Genome Sequencing

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Review

Research Ethics and the Challenge of Whole-Genome Sequencing

Amy L McGuire et al. Nat Rev Genet.

Abstract

The recent completion of the first two individual whole-genome sequences is a research milestone. As personal genome research advances, investigators and international research bodies must ensure ethical research conduct. We identify three major ethical considerations that have been implicated in whole-genome research: the return of research results to participants; the obligations, if any, that are owed to participants' relatives; and the future use of samples and data taken for whole-genome sequencing. Although the issues are not new, we discuss their implications for personal genomics and provide recommendations for appropriate management in the context of research involving individual whole-genome sequencing.

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