Fine-tuning of Cell Signaling by Glypicans

Cell Mol Life Sci. 2011 Mar;68(6):923-9. doi: 10.1007/s00018-007-7471-6. Epub 2011 Feb 22.


Signaling peptides of the extracellular environment regulate cell biological processes underlying embryonic development, tissue homeostasis, and pathophysiology. The heparan sulphate proteoglycans, glypicans, have evolved as essential modulators of key regulatory proteins such as Wnt, Bmp, Fgf, and Shh. By acting on signal spreading and receptor activation, glypicans can control signal read-out and fate in targeted cells. Genetic and embryological studies have highlighted that glypicans act in a temporal and spatially regulated manner to modulate distinct cellular events. However, alterations of glypican function underlie human congenital malformations and cancer. Recent reports are starting to reveal their mechanism of action and how they can ensure tight modulation of cell signaling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arrhythmias, Cardiac / genetics
  • Genes, Tumor Suppressor
  • Genetic Diseases, X-Linked
  • Gigantism / genetics
  • Glypicans / genetics
  • Glypicans / metabolism*
  • Heart Defects, Congenital / genetics
  • Humans
  • Intellectual Disability / genetics
  • Intercellular Signaling Peptides and Proteins / physiology*
  • Models, Molecular*
  • Mutation / genetics
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Neural Stem Cells / metabolism*
  • Oncogenes / genetics
  • Signal Transduction / physiology*


  • GPC3 protein, human
  • GPC4 protein, human
  • Glypicans
  • Intercellular Signaling Peptides and Proteins

Supplementary concepts

  • Simpson-Golabi-Behmel syndrome