Allergy to cassava: a new allergenic food with cross-reactivity to latex

J Investig Allergol Clin Immunol. 2007;17(6):409-12.


Patients who are allergic to latex (Hevea brasiliensis) may exhibit cross-hypersensitivity with foods. We present a case of anaphylaxis due to cassava in a patient suffering from pollinosis, latex allergy, and latex-fruit syndrome. We performed sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting with cassava, avocado, chestnut, banana, kiwi, and latex extracts in order to analyze the protein bands and their molecular weights, and identify immunoglobulin (Ig) E-binding bands. Immunoblot inhibition and enzyme-linked immunosorbent assay (ELISA) inhibition were performed with latex in order to assess cross-reactivity. Cassava exhibited numerous protein bands, 5 of which were IgE-binding (89.75, 46.28, 26.68, 21.38, and 19.49 kd). These cassava IgE-binding bands were 100% inhibited by preincubation of the patient's serum with latex extract. The ELISA inhibition between latex and cassava was 23%. Our results confirm cassava as another food with clinical cross-reactivity in patients suffering from latex allergy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cross Reactions
  • Female
  • Food Hypersensitivity / etiology
  • Food Hypersensitivity / immunology*
  • Humans
  • Latex / immunology*
  • Latex Hypersensitivity / immunology
  • Manihot / immunology*


  • Latex