Recollections on thrombin generation

J Thromb Haemost. 2008 Feb;6(2):219-26. doi: 10.1111/j.1538-7836.2007.02864.x. Epub 2007 Dec 10.

Abstract

Against an autobiographic background, a historical sketch is given of the development of the technique of thrombin generation, from subsampling to duly calibrated continuous measurement with fluorogenic substrates. Its application to various problems in the pathophysiology of hemostasis and thrombosis is discussed.

Publication types

  • Autobiography
  • Biography
  • Historical Article
  • Portrait

MeSH terms

  • Anticoagulants / history
  • Anticoagulants / pharmacology
  • Blood Platelets / physiology
  • Hematology / history*
  • Hemostasis / physiology
  • Heparin, Low-Molecular-Weight / history
  • Heparin, Low-Molecular-Weight / pharmacology
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Netherlands
  • Prothrombin / metabolism
  • Thrombin / biosynthesis
  • Thrombin / history*

Substances

  • Anticoagulants
  • Heparin, Low-Molecular-Weight
  • Prothrombin
  • Thrombin

Personal name as subject

  • H Coenraad Hemker