The role of the extracellular matrix in ovarian follicle development

Reprod Sci. 2007 Dec;14(8 Suppl):6-10. doi: 10.1177/1933719107309818.

Abstract

Regulation of ovarian follicle development depends on endocrine- and paracrine-acting hormones, the 3-dimensional architecture of the follicle, and the physical rigidity of the surrounding tissue. These 3 forces are integrated throughout the life cycle of the follicle to ensure appropriate hormone secretion, differentiation of the somatic cells, and maturation of the oocyte. The process of in-follicle maturation provides a new tool for understanding ovarian follicle development under the influence of these factors.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Aggregation
  • Cell Culture Techniques
  • Cell Differentiation
  • Cell Proliferation
  • Cell Shape
  • Cell Survival
  • Cells, Cultured
  • Estradiol / metabolism
  • Extracellular Matrix / metabolism*
  • Female
  • Granulosa Cells / metabolism
  • Granulosa Cells / physiology
  • Humans
  • Ovarian Follicle / metabolism
  • Ovarian Follicle / physiology*
  • Ovary / metabolism
  • Ovary / physiology*
  • Paracrine Communication*
  • Progesterone / metabolism
  • Signal Transduction*
  • Theca Cells / metabolism
  • Theca Cells / physiology
  • Time Factors

Substances

  • Progesterone
  • Estradiol