Association between SORL1 and Alzheimer's disease in a genome-wide study

Neuroreport. 2007 Nov 19;18(17):1761-4. doi: 10.1097/WNR.0b013e3282f13e7a.


Several studies have reported an association of Alzheimer's disease (AD) with polymorphic markers in SORL1. Data from a recently published genome-wide association study in AD have been made publicly available. We tested the association of AD with SORL1 in this dataset (Translational Genomics Research Institute; TGEN), which included 31 SORL1 single nucleotide polymorphisms (SNPs), eight of which overlapped the original study. Six SNPs, near the 3' region of SORL1 containing SNPs which were strongly associated with AD in previous studies, showed significant association in the TGEN dataset. These results provide an independent replication of the association between AD and SORL1.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / epidemiology
  • Alzheimer Disease / genetics*
  • Databases, Genetic
  • Europe / epidemiology
  • Genome, Human / genetics*
  • Humans
  • LDL-Receptor Related Proteins / genetics*
  • Linkage Disequilibrium / genetics
  • Membrane Transport Proteins / genetics*
  • Polymorphism, Single Nucleotide


  • LDL-Receptor Related Proteins
  • Membrane Transport Proteins
  • SORL1 protein, human